Sarcoma with BCOR gene alterations (BCOR-ITD) of the L3 vertebra in an 8-year-old boy

8-year-old boy with progressive headache.

An 8-year-old boy with no significant past medical history presented to the emergency department following 2 weeks of progressive headaches, fatigue, and vomiting. On physical examination, the patient had no fever, or focal motor or sensory neurological deficits. Initially diagnosed with an H1N1 viral upper respiratory and gastrointestinal infection, he was discharged home with conservative man...

An 8-year-old boy with intermittent pain.

Suicide Attempt in an 8-Year-Old Boy by Hanging Himself Three Times: Case Report

Suicidal behavior in children under the age of 10 years is a warning and worrying phenomenon. This phenomenon can be an important indicator for evaluating the mental health of individuals in community. This study presents an 8-year-old boy who had past history of suicide attempt by hanging three times. The childchr('39')s psychiatric counseling identified that he had Major depression disorder (...

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked BCOR gene encoding BCL6 corepressor (BCOR); however, its tumor suppressor function remains largely uncharacterized. We generated mice missing Bcor exon 4, expressing a variant BCOR lacking the BCL6-binding domain. Although the deletion of exon 4 in male mice (BcorΔE4/y ) compromised the r...

Kienböck's disease in an 8 year old boy.

Kienböck's disease is an uncommon condition occurring in adults but rarely in children. A case occurring in an 8 year old boy is presented. This patient showed a strongly negative ulnar variant, which may have been an aetiological factor in his young presentation.